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Search Results for " tgf-beta receptor type i "

Targets

2

Compounds

52

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T1944 LDN-214117 ALK , TGF-beta/Smad
LDN-214117 is a potent and selective ALK2 inhibitor.
T2098 A 77-01 A77-01 ALK , TGF-beta/Smad
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01178 TGFBR1 Protein, Mouse, Recombinant (hFc) Mouse Human Cells
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Pho...
TMPJ-00261 TGF beta 2 Protein, Mouse/Rat, Recombinant Mouse,Rat Human Cells
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci...
TMPJ-00335 TGFBR2 Protein, Mouse, Recombinant (His) Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPY-01168 ALK-1 Protein, Human, Recombinant (His) Human HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPY-01059 BMPR2 Protein, Human, Recombinant (His) Human HEK293
The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin...
TMPY-05085 LRRC32 Protein, Human, Recombinant (His) Human HEK293
LRRC32 (Leucine-Rich Repeat Containing 32) is a Protein Coding gene. This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. LRRC32, also known as Glycoprotein A Repetitions Predominant (GARP)...
TMPY-04774 ALK-2/ACVR1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been...
TMPY-04366 ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST) Human Baculovirus-Insect Cells
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si...
TMPY-05771 ALK-5 Protein, Human, Recombinant (hFc) Human HEK293
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si...
TMPJ-00256 Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPJ-00255 TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPY-01358 ALK-5 Protein, Human, Recombinant (His & hFc) Human HEK293
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si...
TMPJ-00334 TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPJ-00333 TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc) Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPJ-00771 TGF beta 1 Protein, Mouse/Rat, Recombinant Mouse,Rat Human Cells
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differen...
TMPY-00662 ALK-1 Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPY-03678 ALK-1 Protein, Canine, Recombinant (hFc) Canine HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPY-03315 ALK-1 Protein, Cynomolgus, Recombinant (hFc) Cynomolgus HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPJ-01158 ALK-2/ACVR1 Protein, Human, Recombinant (hFc) Human Human Cells
Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formati...
TMPY-00757 ALK-1 Protein, Rat, Recombinant (His & hFc) Rat HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPY-00310 ALK-1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPY-00650 ALK-1 Protein, Human, Recombinant (hFc) Human HEK293
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPY-00499 TMP21 Protein, Human, Recombinant (mFc) Human HEK293
TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long r...
TMPJ-00315 ACVR2A Protein, Human, Recombinant (hFc & His) Human Human Cells
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation fact...
TMPJ-00314 ACVR2B Protein, Human, Recombinant (hFc & His) Human Human Cells
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors...
TMPH-01701 SMAD6 Protein, Human, Recombinant (His & Myc) Human Baculovirus
Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPH-01702 SMAD6 Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPH-01018 BMP-6 Protein, Human, Recombinant (His) Human E. coli
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Plays also an important role in the regulation of iron metabolism by acting as ...
TMPY-05485 BMPR1A/ALK-3 Protein, Human, Recombinant (hFc) Human HEK293
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta...
TMPY-01764 BMPR1A/ALK-3 Protein, Human, Recombinant (His) Human HEK293
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta...
TMPY-01374 BMPR1A/ALK-3 Protein, Mouse, Recombinant (His) Mouse HEK293
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta...
TMPY-00962 BMPR1A/ALK-3 Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta...
TMPY-00614 BMPR1A/ALK-3 Protein, Canine, Recombinant (hFc) Canine HEK293
Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta...
TMPY-00808 FKBP12 Protein, Human, Recombinant (His) Human E. coli
FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As ...
TMPY-01662 FKBP12 Protein, Mouse, Recombinant (His) Mouse E. coli
FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As ...
TMPY-00683 BMPR2 Protein, Human, Recombinant (His & hFc) Human HEK293
The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin...
TMPY-05375 LRRC32 Protein, Human, Recombinant (His), Biotinylated Human HEK293
LRRC32 (Leucine-Rich Repeat Containing 32) is a Protein Coding gene. This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. LRRC32, also known as Glycoprotein A Repetitions Predominant (GARP)...
TMPY-06705 LRRC32 Protein, Mouse, Recombinant (His) Mouse HEK293
LRRC32 (Leucine-Rich Repeat Containing 32) is a Protein Coding gene. This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. LRRC32, also known as Glycoprotein A Repetitions Predominant (GARP)...
TMPH-01019 BMP-7 Protein, Human, Recombinant (GST) Human E. coli
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling ...
TMPH-01017 BMP-4 Protein, Human, Recombinant (His) Human E. coli
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimu...
TMPY-02962 FKBP7 Protein, Human, Recombinant (hFc) Human HEK293
PPIase is a member of the immunophilin protein family. It also belongs to the cyclophilin-type PPIase family, PPIL3 subfamily. PPIase contains 1 PPIase cyclophilin-type domain. Members of the immunophilin protein family ...
TMPY-03148 FKBP7 Protein, Human, Recombinant (His) Human HEK293
PPIase is a member of the immunophilin protein family. It also belongs to the cyclophilin-type PPIase family, PPIL3 subfamily. PPIase contains 1 PPIase cyclophilin-type domain. Members of the immunophilin protein family ...
TMPY-06703 LRRC32 Protein, Mouse, Recombinant (hFc) Mouse HEK293
LRRC32 (Leucine-Rich Repeat Containing 32) is a Protein Coding gene. This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. LRRC32, also known as Glycoprotein A Repetitions Predominant (GARP)...
TMPH-00228 BMP-4 Protein, Bovine, Recombinant (GST) Bovine E. coli
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimu...
TMPH-01014 BMP-2 Protein, Human, Recombinant (His) Human E. coli
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical...
TMPY-03706 ALK-2/ACVR1 Protein, Canine, Recombinant (hFc) Canine HEK293
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been...
TMPY-03157 ALK-2/ACVR1 Protein, Rat, Recombinant (hFc) Rat HEK293
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been...
TMPY-00658 ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc) Human HEK293
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been...
TMPY-01096 ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been...
TMPY-03707 ALK-2/ACVR1 Protein, Canine, Recombinant (His) Canine HEK293
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been...
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TGFBR1 Protein, Mouse, Recombinant (hFc)
TMPJ-01178
Species: Mouse
Expression System: Human Cells
TGF beta 2 Protein, Mouse/Rat, Recombinant
TMPJ-00261
Species: Mouse,Rat
Expression System: Human Cells
TGFBR2 Protein, Mouse, Recombinant (His)
TMPJ-00335
Species: Mouse
Expression System: Human Cells
ALK-1 Protein, Human, Recombinant (His)
TMPY-01168
Species: Human
Expression System: HEK293
BMPR2 Protein, Human, Recombinant (His)
TMPY-01059
Species: Human
Expression System: HEK293
LRRC32 Protein, Human, Recombinant (His)
TMPY-05085
Species: Human
Expression System: HEK293
ALK-2/ACVR1 Protein, Human, Recombinant (His)
TMPY-04774
Species: Human
Expression System: Baculovirus-Insect Cells
ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)
TMPY-04366
Species: Human
Expression System: Baculovirus-Insect Cells
ALK-5 Protein, Human, Recombinant (hFc)
TMPY-05771
Species: Human
Expression System: HEK293
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00256
Species: Human
Expression System: Human Cells
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00255
Species: Human
Expression System: Human Cells
ALK-5 Protein, Human, Recombinant (His & hFc)
TMPY-01358
Species: Human
Expression System: HEK293
TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)
TMPJ-00334
Species: Mouse
Expression System: Human Cells
TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc)
TMPJ-00333
Species: Mouse
Expression System: Human Cells
TGF beta 1 Protein, Mouse/Rat, Recombinant
TMPJ-00771
Species: Mouse,Rat
Expression System: Human Cells
ALK-1 Protein, Mouse, Recombinant (His & hFc)
TMPY-00662
Species: Mouse
Expression System: HEK293
ALK-1 Protein, Canine, Recombinant (hFc)
TMPY-03678
Species: Canine
Expression System: HEK293
ALK-1 Protein, Cynomolgus, Recombinant (hFc)
TMPY-03315
Species: Cynomolgus
Expression System: HEK293
ALK-2/ACVR1 Protein, Human, Recombinant (hFc)
TMPJ-01158
Species: Human
Expression System: Human Cells
ALK-1 Protein, Rat, Recombinant (His & hFc)
TMPY-00757
Species: Rat
Expression System: HEK293
ALK-1 Protein, Cynomolgus, Recombinant (His)
TMPY-00310
Species: Cynomolgus
Expression System: HEK293
ALK-1 Protein, Human, Recombinant (hFc)
TMPY-00650
Species: Human
Expression System: HEK293
TMP21 Protein, Human, Recombinant (mFc)
TMPY-00499
Species: Human
Expression System: HEK293
ACVR2A Protein, Human, Recombinant (hFc & His)
TMPJ-00315
Species: Human
Expression System: Human Cells
ACVR2B Protein, Human, Recombinant (hFc & His)
TMPJ-00314
Species: Human
Expression System: Human Cells
SMAD6 Protein, Human, Recombinant (His & Myc)
TMPH-01701
Species: Human
Expression System: Baculovirus
SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-01702
Species: Human
Expression System: E. coli
BMP-6 Protein, Human, Recombinant (His)
TMPH-01018
Species: Human
Expression System: E. coli
BMPR1A/ALK-3 Protein, Human, Recombinant (hFc)
TMPY-05485
Species: Human
Expression System: HEK293
BMPR1A/ALK-3 Protein, Human, Recombinant (His)
TMPY-01764
Species: Human
Expression System: HEK293
BMPR1A/ALK-3 Protein, Mouse, Recombinant (His)
TMPY-01374
Species: Mouse
Expression System: HEK293
BMPR1A/ALK-3 Protein, Mouse, Recombinant (His & hFc)
TMPY-00962
Species: Mouse
Expression System: HEK293
BMPR1A/ALK-3 Protein, Canine, Recombinant (hFc)
TMPY-00614
Species: Canine
Expression System: HEK293
FKBP12 Protein, Human, Recombinant (His)
TMPY-00808
Species: Human
Expression System: E. coli
FKBP12 Protein, Mouse, Recombinant (His)
TMPY-01662
Species: Mouse
Expression System: E. coli
BMPR2 Protein, Human, Recombinant (His & hFc)
TMPY-00683
Species: Human
Expression System: HEK293
LRRC32 Protein, Human, Recombinant (His), Biotinylated
TMPY-05375
Species: Human
Expression System: HEK293
LRRC32 Protein, Mouse, Recombinant (His)
TMPY-06705
Species: Mouse
Expression System: HEK293
BMP-7 Protein, Human, Recombinant (GST)
TMPH-01019
Species: Human
Expression System: E. coli
BMP-4 Protein, Human, Recombinant (His)
TMPH-01017
Species: Human
Expression System: E. coli
FKBP7 Protein, Human, Recombinant (hFc)
TMPY-02962
Species: Human
Expression System: HEK293
FKBP7 Protein, Human, Recombinant (His)
TMPY-03148
Species: Human
Expression System: HEK293
LRRC32 Protein, Mouse, Recombinant (hFc)
TMPY-06703
Species: Mouse
Expression System: HEK293
BMP-4 Protein, Bovine, Recombinant (GST)
TMPH-00228
Species: Bovine
Expression System: E. coli
BMP-2 Protein, Human, Recombinant (His)
TMPH-01014
Species: Human
Expression System: E. coli
ALK-2/ACVR1 Protein, Canine, Recombinant (hFc)
TMPY-03706
Species: Canine
Expression System: HEK293
ALK-2/ACVR1 Protein, Rat, Recombinant (hFc)
TMPY-03157
Species: Rat
Expression System: HEK293
ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc)
TMPY-00658
Species: Human
Expression System: HEK293
ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc)
TMPY-01096
Species: Mouse
Expression System: HEK293
ALK-2/ACVR1 Protein, Canine, Recombinant (His)
TMPY-03707
Species: Canine
Expression System: HEK293
Cat No. Product Name
L4100 TGF-beta/Smad Compound Library

184 compounds
A unique collection of 184 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;
TargetMol